Pre-structured hydrophobic peptide β-strands: A universal amyloid trap?
نویسندگان
چکیده
منابع مشابه
Probing aromatic, hydrophobic, and steric effects on the self-assembly of an amyloid-β fragment peptide.
Aromatic amino acids have been shown to promote self-assembly of amyloid peptides, although the basis for this amyloid-inducing behavior is not understood. We adopted the amyloid-β 16-22 peptide (Aβ(16-22), Ac-KLVFFAE-NH(2)) as a model to study the role of aromatic amino acids in peptide self-assembly. Aβ(16-22) contains two consecutive Phe residues (19 and 20) in which Phe 19 side chains form ...
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ژورنال
عنوان ژورنال: Archives of Biochemistry and Biophysics
سال: 2019
ISSN: 0003-9861
DOI: 10.1016/j.abb.2019.01.032